AMD designs CPUs and GPU accelerators for data centers, PCs, and embedded applications. Its EPYC server CPUs compete with Intel Xeon in enterprise and cloud markets, while its Instinct GPU line targets AI training and inference in data centers. AMD operates as a fabless company, relying primarily on TSMC for manufacturing its most advanced chips.

The AI compute era has elevated AMD's data center GPU business from a secondary product line to a primary growth driver. Starting with the MI300X in late 2023—its first GPU competitive with Nvidia's H100 for large language model inference—AMD pursued an annual GPU release cadence and built out its ROCm open-source software stack as an alternative to Nvidia's CUDA ecosystem. The strategy attracted hyperscaler and enterprise customers seeking supply diversification. Microsoft and Meta deployed MI300X at scale, and AMD's data center segment reached approximately $16B in annual revenue in 2025.

In 2025, AMD launched the Instinct MI350 series and announced the MI400 and Helios rack-scale solution for 2026. Meta confirmed broad deployment of MI300X for Llama 3 and Llama 4 inference. AMD also signed a partnership with OpenAI for 6 GW of Instinct GPU deployments and a collaboration with HUMAIN in Saudi Arabia for 500 MW of AI compute capacity. The company launched ROCm 7 and the AMD Developer Cloud to reduce the software barrier for developers adopting its platform.